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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUK1
All Species:
22.42
Human Site:
S158
Identified Species:
41.11
UniProt:
Q16774
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16774
NP_000849.1
197
21726
S158
A
A
Q
A
D
M
E
S
S
K
E
P
G
L
F
Chimpanzee
Pan troglodytes
XP_001142469
475
50955
S224
A
A
Q
A
D
M
E
S
K
D
S
A
A
P
N
Rhesus Macaque
Macaca mulatta
XP_001084363
197
21679
S158
A
A
R
A
D
M
E
S
S
K
E
P
G
L
F
Dog
Lupus familis
XP_532411
198
21967
S158
A
A
Q
V
D
M
E
S
S
K
E
Q
G
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q64520
198
21899
S158
A
A
R
T
D
M
E
S
S
K
E
P
G
L
F
Rat
Rattus norvegicus
NP_001013133
219
24034
S179
A
A
Q
A
D
M
E
S
S
K
E
P
G
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232001
198
22316
L158
A
A
R
V
D
L
E
L
S
K
E
P
G
L
F
Frog
Xenopus laevis
NP_001087146
198
21955
I158
A
A
I
E
D
L
E
I
S
K
E
P
G
L
F
Zebra Danio
Brachydanio rerio
NP_001002126
199
21965
I158
A
A
K
V
D
V
E
I
S
K
E
P
G
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648408
233
25880
Y189
A
A
Q
V
E
L
D
Y
G
L
T
P
G
N
F
Honey Bee
Apis mellifera
XP_624407
194
22137
Q149
E
T
E
D
V
L
K
Q
R
L
S
I
A
K
V
Nematode Worm
Caenorhab. elegans
NP_491243
216
24871
E178
H
A
S
E
D
L
V
E
I
E
K
N
P
T
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P15454
187
20619
N145
T
E
T
E
E
S
I
N
K
R
L
S
A
A
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.1
98.4
88.8
N.A.
87.8
78
N.A.
N.A.
73.2
68.1
71.8
N.A.
47.6
54.3
50
N.A.
Protein Similarity:
100
40.4
98.9
92.9
N.A.
92.9
84.4
N.A.
N.A.
87.3
82.3
84.9
N.A.
60.5
73
63.4
N.A.
P-Site Identity:
100
53.3
93.3
86.6
N.A.
86.6
100
N.A.
N.A.
73.3
73.3
73.3
N.A.
40
0
13.3
N.A.
P-Site Similarity:
100
53.3
100
86.6
N.A.
93.3
100
N.A.
N.A.
86.6
80
86.6
N.A.
60
20
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
68.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
77
85
0
31
0
0
0
0
0
0
0
8
24
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
77
0
8
0
0
8
0
0
0
0
0
% D
% Glu:
8
8
8
24
16
0
70
8
0
8
62
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
70
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
70
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
8
16
8
0
0
8
0
0
0
% I
% Lys:
0
0
8
0
0
0
8
0
16
62
8
0
0
8
0
% K
% Leu:
0
0
0
0
0
39
0
8
0
16
8
0
0
62
8
% L
% Met:
0
0
0
0
0
47
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
8
0
8
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
62
8
8
0
% P
% Gln:
0
0
39
0
0
0
0
8
0
0
0
8
0
0
8
% Q
% Arg:
0
0
24
0
0
0
0
0
8
8
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
8
0
47
62
0
16
8
0
0
0
% S
% Thr:
8
8
8
8
0
0
0
0
0
0
8
0
0
8
0
% T
% Val:
0
0
0
31
8
8
8
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _